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Updated: Feb 12, 2026
10:35
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
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Ovarian Cancer Prevention and Screening
Usha Menon1, Chloe Karpinskyj, Aleksandra Gentry-Maharaj
1Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom.
Obstetrics and Gynecology
|April 10, 2018
Summary
Recent advancements in ovarian cancer screening include improved risk prediction tools and surgical prevention strategies like bilateral salpingectomy. Multimodal screening shows promise, but definitive mortality reduction requires further study.
Area of Science:
- Gynecologic Oncology
- Preventive Medicine
- Cancer Screening
Background:
- Ovarian cancer screening and prevention have seen significant progress.
- Emerging evidence suggests tubal origins for some ovarian cancers, influencing surgical strategies.
- Personalized risk assessment using genetic and epidemiologic factors is becoming available.
Purpose of the Study:
- To review recent advancements in ovarian cancer screening and prevention strategies.
- To discuss the role of surgical interventions and chemoprevention.
- To evaluate the effectiveness of multimodal screening approaches.
Main Methods:
- Review of recent clinical trials and screening studies, including the UK Collaborative Trial of Ovarian Cancer Screening.
- Analysis of surgical interventions such as bilateral salpingectomy and risk-reducing salpingo-oophorectomy.
- Evaluation of chemoprevention strategies, including oral contraceptive pills for BRCA mutation carriers.
Main Results:
- Multimodal screening using the longitudinal CA 125 Risk of Ovarian Cancer Algorithm showed a stage shift, unlike transvaginal ultrasound alone.
- Opportunistic bilateral salpingectomy is being adopted for prevention.
- Risk-reducing salpingo-oophorectomy remains standard for high-risk individuals, with focus on managing side effects.
- Longitudinal algorithms outperform single cutoffs for CA 125 in screening.
Conclusions:
- While general population screening lacks definitive mortality reduction evidence, high-risk screening recommendations vary.
- Surgical prevention strategies are evolving, with ongoing trials on endocrine function.
- Further research into novel biomarkers, including DNA markers in plasma and cervical cytology, is crucial.
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