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Related Experiment Videos

Activated suppressor cell function in multiple sclerosis--clinical correlations.

J Antel1, M Brown, M K Nicholas

  • 1Department of Neurology, McGill University, Montreal, QC, Canada.

Journal of Neuroimmunology
|March 1, 1988
PubMed
Summary
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Activated suppressor cell function is impaired in multiple sclerosis (MS) patients, particularly those with progressive disease. Stable MS patients show partial defects in CD8+ cell suppressor activity, indicating a progressive-specific immune dysfunction.

Area of Science:

  • Immunology
  • Neuroimmunology
  • Cell Biology

Background:

  • Reduced activated suppressor cell function is observed in progressive multiple sclerosis (MS-P) patients.
  • CD8+ lymphocytes and mononuclear cells (MNCs) mediate suppressor cell function.

Purpose of the Study:

  • To investigate differences in activated suppressor cell function between stable MS (MS-S) and progressive MS (MS-P) patients.
  • To determine if CD8+ cell lines exhibit distinct suppressor activity patterns in different MS disease courses.

Main Methods:

  • Cultured CD8+ cell lines from MS-S and MS-P patients for 14 days.
  • Assessed suppressor activity of CD8+ cell lines and MNCs.
  • Measured cytotoxic activity, proliferation rates (with IL-2 and OKT3), and IL-2 dependency.

Related Experiment Videos

Main Results:

  • CD8+ cell lines from MS-S patients showed significantly greater suppressor activity (45%) than MS-P patients (11%).
  • MS-S suppressor values were suggestively reduced compared to controls (60% vs. 67%).
  • MNC suppressor values were significantly reduced in MS-P (7%) compared to MS-S (61%) and controls (67%).
  • Cytotoxic activity and proliferation rates did not differ between MS and control CD8+ cell lines.
  • Suppressor function was dependent on exogenous IL-2.

Conclusions:

  • Defective activated suppressor function is characteristic of progressive MS.
  • A partial suppressor defect in CD8+ cell lines is also evident in stable MS patients.
  • The findings highlight a progressive-specific immune dysfunction involving CD8+ T-cell suppressor activity.