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Related Experiment Videos

Do serotonin uptake inhibitors decrease smoking? Observations in a group of heavy drinkers.

E M Sellers1, C A Naranjo, K Kadlec

  • 1Clinical Pharmacology Program, University of Toronto, Ontario, Canada.

Journal of Clinical Psychopharmacology
|December 1, 1987
PubMed
Summary

Selective serotonin reuptake inhibitors (SSRIs) like zimelidine and citalopram did not reduce smoking in heavy drinkers. These drugs may affect different addictive behaviors differently.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Serotonin uptake inhibitors (SUIs) influence consummatory and drug self-administration behaviors.
  • Previous research suggests potential therapeutic applications for SUIs in humans.

Purpose of the Study:

  • To evaluate the effects of zimelidine and citalopram on smoking behavior in heavy drinkers.
  • To determine if SUIs, known to affect ethanol intake, also impact smoking habits.

Main Methods:

  • A double-blind, placebo-controlled crossover study design was employed.
  • Participants received either zimelidine (200 mg/day) or placebo.
  • Another group received citalopram (20 or 40 mg/day) or placebo.
  • Subjects were not instructed to alter their smoking or drinking habits.

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Main Results:

  • Zimelidine showed no significant effect on the number of cigarettes smoked.
  • Neither dose of citalopram demonstrated a significant impact on smoking behavior.
  • The study was adequately powered to exclude a 50% reduction in smoking with high confidence.

Conclusions:

  • Zimelidine and citalopram do not appear to reduce smoking behavior in heavy drinkers.
  • These findings suggest that SUIs may have differential effects on various consummatory behaviors, impacting ethanol intake but not smoking.