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Salivary biomarkers and cardiovascular disease: a systematic review

Vishal Gohel1, Judith A Jones2,3, Carolyn J Wehler2

  • 1Boston University Henry M. Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118-2308, USA.

Clinical Chemistry and Laboratory Medicine
|April 10, 2018
PubMed

Insights

Salivary biomarkers show potential for assessing cardiovascular disease (CVD) risk. While C-reactive protein (CRP) in saliva consistently correlates with CVD, other biomarkers yield conflicting results, requiring further research.

Area of Science:

  • Biomarkers
  • Cardiovascular Disease Research
  • Salivary Diagnostics

Background:

  • Cardiovascular disease (CVD) poses a significant global health challenge.
  • Non-invasive diagnostic methods for CVD are highly sought after.
  • Salivary biomarkers offer a promising avenue for CVD assessment.

Purpose of the Study:

  • To systematically review and summarize existing literature on salivary biomarkers and their association with CVD status.
  • To identify commonly studied salivary biomarkers in relation to CVD.
  • To evaluate the consistency and trends of these biomarkers in CVD assessment.

Main Methods:

  • A comprehensive literature search was performed across PubMed, Web of Science, and Google Scholar.
  • MeSH terms related to salivary biomarkers and CVD were utilized.
  • Included articles underwent quality assessment using the Newcastle-Ottawa scale.

Main Results:

  • Forty salivary biomarkers were analyzed across 22 selected studies.
  • Salivary C-reactive protein (CRP) demonstrated the most consistent association with CVD.
  • Statistically significant increases in salivary CRP were observed in all studies that analyzed it in relation to CVD.
  • Other biomarkers like creatine kinase isoform MB, matrix metalloproteinase-9, and troponin I showed varying patterns.

Conclusions:

  • Current evidence suggests an association between certain salivary biomarkers and CVD.
  • Conflicting data exists for many biomarkers, necessitating further investigation.
  • Saliva holds promise as a non-invasive tool for cardiovascular risk assessment, despite inconclusive findings.
Abstract

Keywords:
biomarkerscardiovascular diseasediagnosticspoint of caresalivaserum

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