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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
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Inflammatory Bacteriome and Oral Squamous Cell Carcinoma.
M Perera1,2, N N Al-Hebshi3, I Perera4
11 School of Dentistry and Oral Health, Griffith University, Queensland, Australia.
Journal of Dental Research
|April 10, 2018
Summary
This study found that oral squamous cell carcinoma (OSCC) tissues have an inflammatory bacteriome, with specific bacterial genes linked to inflammation, supporting a role for the microbiome in oral cancer development.
Area of Science:
- Microbiology
- Oncology
- Genomics
Background:
- Oral microbiome studies for oral cancer yield inconsistent results due to focus on composition over function.
- Functional prediction studies suggest inflammatory bacterial attributes are enriched in oral squamous cell carcinoma (OSCC).
Purpose of the Study:
- To corroborate findings of enriched inflammatory bacterial attributes in OSCC.
- To investigate the oral bacteriome's functional and compositional differences in OSCC versus benign controls.
Main Methods:
- Case-control study comparing 25 OSCC cases and 27 fibroepithelial polyp (FEP) controls.
- DNA sequencing of V1-V3 regions and species-level classification using BLASTN.
- Microbiome compositional analysis (QIIME, LEfSe) and functional prediction (PICRUSt).
Main Results:
- OSCC tissues showed reduced species richness and diversity compared to FEP controls.
- Specific genera (Capnocytophaga, Pseudomonas, Atopobium) and species (e.g., Campylobacter concisus) were enriched in OSCC.
- Functionally, OSCC tissues exhibited enrichment of proinflammatory bacterial attributes, including lipopolysaccharide biosynthesis and peptidases.
Conclusions:
- While species composition differed from prior studies, functional analysis consistently showed an inflammatory bacteriome associated with OSCC.
- These findings support the role of an inflammatory oral microbiome in the carcinogenesis of OSCC.
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