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Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive?
Jisun Paik1, Piper M Treuting1, Michael Haenisch1
1Department of Comparative Medicine, University of Washington, Seattle, WA, USA.
Objective:
Vitamin A deficient females have reduced fertility due to decreased retinoic acid production. WIN 18,446 inhibits retinoic acid biosynthesis and functions as a contraceptive in males. We tested whether WIN 18,446 treatment would suppress fertility in female mice.
Study Design:
Female mice were treated with WIN 18,446 and mated. Pregnancy rates were compared using Fisher's exact test.
Results:
WIN 18,446 reduced pregnancy compared with control (p=.03). However, one animal became pregnant with malformed embryos.
Conclusions:
WIN 18,446 treatment significantly reduces fecundity, but teratogenicity in the setting of contraceptive failure limits the appeal of this approach to female contraception.
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