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Updated: Feb 12, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
Published on: August 10, 2017
Golgi bypass for local delivery of axonal proteins, fact or fiction?
Carolina González1, Víctor Hugo Cornejo1, Andrés Couve1
1Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Chile; Biomedical Neuroscience Institute (BNI), Facultad de Medicina, Universidad de Chile, Chile.
Abstract:
Although translation of cytosolic proteins is well described in axons, much less is known about the synthesis, processing and trafficking of transmembrane and secreted proteins. A canonical rough endoplasmic reticulum or a stacked Golgi apparatus has not been detected in axons, generating doubts about the functionality of a local route. However, axons contain mRNAs for membrane and secreted proteins, translation factors, ribosomal components, smooth endoplasmic reticulum and post-endoplasmic reticulum elements that may contribute to local biosynthesis and plasma membrane delivery. Here we consider the evidence supporting a local secretory system in axons. We discuss exocytic elements and examples of autonomous axonal trafficking that impact development and maintenance. We also examine whether unconventional post-endoplasmic reticulum pathways may replace the canonical Golgi apparatus.
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