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pH-sensitive charge-conversional and NIR responsive bubble-generating liposomal system for synergetic
Ming-Mao Chen1, Fei-Fei Song1, Mei Feng2
1Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 350002, China.
Colloids and Surfaces. B, Biointerfaces
|April 10, 2018
Summary
This study presents a novel liposomal system (PSD/DOX/Cypate-BTSL) for enhanced cancer therapy. The system utilizes near-infrared (NIR) light to trigger rapid drug release and improve therapeutic outcomes.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Developing advanced drug delivery systems is crucial for improving cancer therapy efficacy.
- Liposomes offer a versatile platform for encapsulating therapeutic agents.
- Stimuli-responsive systems enhance targeted drug delivery and reduce side effects.
Purpose of the Study:
- To develop a charge-conversional, NIR-responsive liposomal system (PSD/DOX/Cypate-BTSL) for enhanced cancer treatment.
- To investigate the synergistic effects of photothermal therapy (PTT) and chemotherapy.
- To evaluate the pH-responsive charge reversal and rapid drug release capabilities.
Main Methods:
- Fabrication of cationic liposomes loaded with doxorubicin (DOX) and NH4HCO3, shielded with pH-sensitive poly(methacryloyl sulfadimethoxine) (PSD).
- Evaluation of pH-triggered charge reversal at tumor-specific pH (6.5).
- Assessment of drug release kinetics under NIR irradiation and hyperthermia.
- In vitro studies on 4T1 cells to assess cellular uptake and cytotoxicity.
- In vivo studies in tumor-bearing models to evaluate tumor accumulation and antitumor efficacy.
Main Results:
- The PSD/DOX/Cypate-BTSL system exhibited pH-sensitive charge reversal at pH 6.5.
- NIR irradiation significantly enhanced doxorubicin release, attributed to Cypate-induced hyperthermia and NH4HCO3 decomposition into CO2 bubbles.
- Enhanced cellular uptake and cytotoxicity were observed in 4T1 cells under irradiation at pH 6.5.
- In vivo studies demonstrated improved tumor accumulation, enhanced antitumor efficacy, and reduced systemic toxicity.
Conclusions:
- The developed PSD/DOX/Cypate-BTSL liposomal system is effective for synergistic photothermal therapy and chemotherapy.
- The charge-conversional and NIR-responsive properties facilitate targeted drug delivery and rapid release.
- This system shows significant potential for improving cancer treatment outcomes with reduced side effects.
Keywords:
Bubble-generatingCharge-conversionNIR responsiveThermo-chemotherapyThermosensive liposomespH-sensitiveMore Related Videos
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