Related Experiment Video

Updated: Feb 12, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Anti-Angiogenics: Their Value in Lung Cancer Therapy

Melanie Janning, Sonja Loges

    Oncology Research and Treatment
    |April 10, 2018
    PubMed

    Insights

    Anti-angiogenic drugs significantly improve outcomes for non-small cell lung cancer (NSCLC) patients. Research focuses on biomarkers and novel targets beyond VEGF to enhance anti-angiogenic therapy effectiveness.

    Area of Science:

    • Oncology
    • Pharmacology
    • Cancer Research

    Background:

    • Lung cancer is a leading cause of cancer-related mortality.
    • Anti-angiogenic therapies, including VEGF inhibitors, are crucial in treating non-small cell lung cancer (NSCLC).
    • Approved agents like bevacizumab, ramucirumab, and nintedanib are used in various treatment lines for advanced NSCLC.

    Purpose of the Study:

    • To review pivotal clinical trials of anti-angiogenic drugs in NSCLC.
    • To provide an overview of current treatment algorithms incorporating anti-angiogenic therapy.
    • To highlight future research directions and novel therapeutic targets.

    Main Methods:

    • Systematic review of pivotal clinical trials involving anti-angiogenic drugs in NSCLC.
    • Analysis of current treatment guidelines and therapeutic positioning.
    • Exploration of emerging research in predictive biomarkers and novel targets.

    Main Results:

    • Anti-angiogenic drugs are established components in first-line (bevacizumab) and second-line (ramucirumab, nintedanib) NSCLC treatment.
    • The review summarizes efficacy data from key trials across different NSCLC settings.
    • Future directions emphasize biomarker discovery and targeting beyond the VEGF axis.

    Conclusions:

    • Anti-angiogenic therapies have significantly improved outcomes in NSCLC.
    • Identifying predictive biomarkers is essential for optimizing patient selection and treatment success.
    • Exploring novel targets within the tumor microenvironment and endothelial metabolism holds promise for future therapeutic advancements.
    Keywords:
    Anti-angiogenesisDisease managementNon-small cell lung cancer, NSCLC

    More Related Videos

    Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients07:43

    Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

    Published on: September 25, 2018

    11.1K
    Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy08:17

    Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

    Published on: June 7, 2015

    16.2K

    Related Concept Videos

    Cancer Therapies02:49

    Cancer Therapies

    Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
    However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
    10.2K
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against...
    9.0K
    Lung Capacity01:47

    Lung Capacity

    The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
    56.4K
    Gene Therapy00:59

    Gene Therapy

    Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
    27.7K
    Group Therapy01:26

    Group Therapy

    Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
    460
    Behavior Therapy01:22

    Behavior Therapy

    Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
    Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
    732