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Polymorphism of CONNEXIN37 gene is a risk factor for ischemic stroke in Han Chinese population

Hong Li1, Shasha Yu2, Rui Wang2

  • 1Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

Lipids in Health and Disease
|April 11, 2018
PubMed

Insights

Connexin37 gene variations are linked to increased ischemic stroke risk in the Han Chinese population. Specific genotypes of Connexin37 single nucleotide polymorphisms (SNPs) were identified as risk factors for this condition.

Area of Science:

  • Genetics
  • Neurology
  • Cardiovascular Research

Background:

  • Stroke poses a significant global health burden due to high fatality and disability rates.
  • Identifying reliable biomarkers is crucial for developing effective stroke prevention and treatment strategies.
  • Connexin37, an anti-inflammatory cytokine, is implicated in chronic inflammation and atherosclerosis, with prior studies suggesting links between its gene variations and atherosclerosis-related diseases like stroke.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the Connexin37 gene and the risk of ischemic stroke.
  • To determine if Connexin37 gene variations serve as potential biomarkers for ischemic stroke in the Han Chinese population.

Main Methods:

  • Analysis of two Connexin37 gene SNPs in 385 ischemic stroke patients and 362 hypertension controls.
  • Utilized the ligase detection reaction (LDR) method for SNP genotyping.

Main Results:

  • Logistic regression revealed that AG and GG genotypes of Connexin37 SNP rs1764390, and the CC genotype of rs1764391, are associated with an elevated risk of ischemic stroke.
  • The G allele of rs1764390 was identified as a significant risk factor for ischemic stroke.
  • Both SNP rs1764390 and SNP rs1764391 were found to be associated with ischemic stroke risk under various genetic models (additive/dominant and recessive/dominant).

Conclusions:

  • Connexin37 gene polymorphism represents a risk factor for ischemic stroke.
  • These findings are specific to the Northern Han Chinese population and highlight the role of Connexin37 in stroke etiology.
Abstract

Keywords:
Gene polymorphismHan ChineseSNPsStrokeconnexin37

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