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Hormone Levels and Sexual Functioning After Risk-Reducing Salpingo-Oophorectomy
Nora Johansen1, Astrid H Liavaag1, Lars Mørkrid2
1Department of Gynecology, Sørlandet Hospital Arendal, Arendal, Norway.
Sexual Medicine
|April 11, 2018
Summary
Hormone levels did not significantly impact sexual pleasure after risk-reducing salpingo-oophorectomy (RRSO). However, systemic hormone replacement therapy (HRT) and other factors positively influenced sexual functioning in these women.
Area of Science:
- Reproductive Endocrinology
- Gynecologic Oncology
- Sexual Medicine
Background:
- Women undergoing risk-reducing salpingo-oophorectomy (RRSO) may experience impaired sexual functioning.
- The relationship between hormone levels and sexual function post-RRSO remains unclear.
Purpose of the Study:
- To investigate the association between hormone levels and sexual functioning in women after RRSO.
- To identify factors influencing sexual activity and satisfaction in this population.
Main Methods:
- Retrospective cohort study including 198 sexually active and 91 inactive women post-RRSO.
- Assessment of sexual functioning using the Sexual Activity Questionnaire.
- Evaluation of hormone replacement therapy (HRT), quality of life, partner care, body image, and comorbidities via questionnaires and blood samples.
Main Results:
- No hormone levels were associated with sexual pleasure; age, systemic HRT, and partner care were significant factors.
- Increased free androgen index, systemic HRT, greater partner care, and no history of cardiovascular disease correlated with less sexual discomfort.
- Sexual activity was positively associated with younger age, no history of breast cancer, better quality of life, and increased partner care.
Conclusions:
- Factors beyond hormone levels are crucial for sexual functioning post-RRSO.
- Systemic HRT demonstrates a positive impact on sexual functioning.
- Further research is warranted on testosterone therapy and the inverse association between free androgen levels and sexual discomfort.
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