Related Experiment Video
Updated: Feb 12, 2026
07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
5.6K
The microbiota, a necessary element of immunity
1Institut Pasteur, Microenvironment & Immunity Unit, 75724 Paris, France; INSERM U1224, 75724 Paris, France.
Comptes Rendus Biologies
|April 11, 2018
Summary
The intestinal microbiota plays a crucial role in digestion and immunity. Proper immune system development requires interaction with gut microbes, impacting inflammatory responses throughout life.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- The intestinal microbiota, comprising over 10^13 bacteria, is vital for digestion, metabolite production, and host defense.
- The immune system's role is to distinguish pathogens from mutualists, but it reacts to all microbes.
Purpose of the Study:
- To investigate the necessity of immune reactivity to the microbiota for proper immune system development and function.
- To understand the consequences of perturbed host-microbe interactions on immune system imprinting and inflammatory pathology.
Main Methods:
- This study focuses on the immunological interactions between the host and the intestinal microbiota.
- Analysis of host-microbe cross-talk during critical developmental windows (prenatal and weaning).
Main Results:
- Immune reactivity to the microbiota is essential for the normal development of the immune system.
- Perturbations in host-microbe interactions before weaning can lead to "pathological imprinting".
Conclusions:
- Altered immune responses due to early-life microbial exposure increase susceptibility to inflammatory diseases later in life.
- Maintaining appropriate immune reactivity to the microbiota is crucial for immune regulation and homeostasis in adulthood.
Related Concept Videos
01:27Elements and Compounds
105.3K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
105.3K
01:38What is the Immune System?
132.4K
Overview
132.4K
04:00Periodic Classification of the Elements
59.6K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
59.6K
02:54Classification of Elements and Compounds
73.6K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
73.6K
02:35Key Elements for Plant Nutrition
24.4K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.4K
02:31Elements: Chemical Symbols and Isotopes
127.3K
A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is used to indicate one atom of mercury (microscopic domain) or to label a container of many atoms of the element mercury (macroscopic domain).
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...
127.3K