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Related Experiment Video

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Sex Differences in Mouse Hippocampal Astrocytes after In-Vitro Ischemia

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Published on: October 25, 2016

Sex Differences in Recombination in Sticklebacks.

Jason M Sardell¹, Changde Cheng², Andrius J Dagilis²

¹Department of Integrative Biology, University of Texas at Austin, Texas 78712 jsardell@austin.utexas.edu.

G3 (Bethesda, Md.)

|April 11, 2018

Summary

This summary is machine-generated.

Female sticklebacks exhibit significantly higher recombination rates than males, with crossovers distributed differently across chromosomes. This sex-specific recombination impacts genomic differentiation between species.

Keywords:

chromosome center biased differentiation genomic differentiation heterochiasmy recombination sex chromosomes

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Area of Science:

Genetics
Evolutionary Biology
Genomics

Background:

Recombination rates and patterns often vary between sexes, a phenomenon known as sexual dimorphism in recombination.
Understanding these differences is crucial for comprehending genome evolution, species divergence, and the dynamics of selection.

Purpose of the Study:

To investigate sex-specific recombination patterns in Gasterosteus sticklebacks.
To analyze the influence of sex on crossover distribution and its correlation with genomic differentiation.

Main Methods:

Whole-genome sequencing of 15 crosses between G. aculeatus and G. nipponicus.
Localization of 698 crossovers with high resolution (median 2.3 kb).
Bioinformatic inference of historical sex-averaged recombination patterns.

Main Results:

Recombination is 1.64 times longer in females than males across all chromosomes.
Male recombination clusters towards chromosome ends, while female recombination is more evenly distributed.
Male centromeres strongly suppress recombination, particularly on short arms, an effect weaker in females.
Genomic differentiation between G. aculeatus and G. nipponicus correlates with recombination rate, influenced by male-specific centromeric and telomeric effects.

Conclusions:

Significant sexual dimorphism in recombination exists in Gasterosteus sticklebacks, with distinct crossover patterns in males and females.
Centromeric regions show stronger recombination suppression in males, driving crossover clustering at chromosome ends.
Sex-specific recombination patterns play a key role in shaping genomic differentiation and may influence evolutionary processes like sexually antagonistic selection.