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Prohormone processing reactions: discrete stages in the formation of beta-endorphin related peptides
N J Darby1, K Maruthainar, D G Smyth
1National Institute for Medical Research, London, U.K.
NIDA Research Monograph
|January 1, 1986
Abstract:
Analysis of lipotropin from the pars intermedia of bovine pituitary showed that it contained the full COOH-terminal sequence of beta-endorphin. In contrast the beta-endorphin related peptides exhibited a high degree of C-terminal proteolysis. The implications of these findings are discussed with reference to the cellular compartments where the processing reactions take place.