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Related Concept Videos

Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acid Structure01:25

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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Nucleic Acids and Nucleotides01:20

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

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Molecular spherical nucleic acids.

Hui Li1, Bohan Zhang1, Xueguang Lu2

  • 1Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, 410082 Changsha, China.

Proceedings of the National Academy of Sciences of the United States of America
|April 11, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed novel molecular spherical nucleic acid (SNA) nanostructures using buckminsterfullerene C60 scaffolds. These SNAs efficiently regulate gene expression as antisense agents without needing transfection agents.

Keywords:
gene regulationmolecular nanoconjugatesoligonucleotidesspherical nucleic acids

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Area of Science:

  • Nanotechnology
  • Molecular Biology
  • Biochemistry

Background:

  • Spherical nucleic acids (SNAs) are promising for gene regulation.
  • Conventional SNAs often use gold nanoparticles, leading to polydispersity.
  • Developing molecularly pure SNAs is crucial for controlled cellular interactions.

Purpose of the Study:

  • To synthesize and characterize novel molecular spherical nucleic acid (SNA) nanostructures.
  • To compare the properties of SNAs based on different molecular scaffolds.
  • To evaluate the potential of these SNAs as gene regulation agents.

Main Methods:

  • Synthesis of SNA nanostructures using T8 polyhedral silsesquioxane and buckminsterfullerene C60 scaffolds.
  • Modification of scaffolds with pendant DNA strands to create varying surface densities.
  • Assessment of nuclease resistance, cellular uptake, and gene regulation capabilities.

Main Results:

  • Two types of molecular SNAs were synthesized with distinct DNA surface densities.
  • The C60 SNA conjugate demonstrated properties similar to gold nanoparticle SNAs.
  • The C60 SNA functioned as an effective antisense agent, regulating gene expression without transfection agents.

Conclusions:

  • Molecularly pure SNAs offer enhanced control over cellular interactions compared to polydisperse forms.
  • Buckminsterfullerene C60-based SNAs show significant potential for gene regulation applications.
  • These novel SNAs represent a step towards more precise molecular medicine and diagnostics.