Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme.

Modern rheumatology·2026
Same author

Fatal Pericarditis and Cardiac Tamponade During Selumetinib Treatment for Pericardial Neurofibroma.

The Journal of dermatology·2026
Same author

Author Correction: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.

Nature communications·2026
Same author

Focal dermal hypoplasia with clinical features mimicking classic hypohidrotic ectodermal dysplasia and cardiofaciocutaneous syndrome.

European journal of dermatology : EJD·2025
Same author

Cardiovascular complication by COVID-19 infection in SSc patients with anti-RNA polymerase III antibody.

Rheumatology (Oxford, England)·2025
Same author

Clinical and Epidemiological Features of Juvenile-Onset Systemic Sclerosis From a Nationwide Survey in Japan.

The Journal of rheumatology·2025

Related Experiment Video

Updated: Feb 12, 2026

Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

16.1K

[Dermatomyositis and Autoantibodies].

Manabu Fujimoto1

  • 1Department of Dermatology, Faculty of Medicine, University of Tsukuba.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|April 11, 2018
PubMed
Summary
This summary is machine-generated.

New dermatomyositis autoantibodies are key for classifying patients. These specific antibodies correlate with clinical issues like lung disease and cancer, aiding in disease subset identification.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.9K
Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

881

Related Experiment Videos

Last Updated: Feb 12, 2026

Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

16.1K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.9K
Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

881

Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Dermatomyositis is a complex autoimmune disease with varied clinical presentations.
  • Disease-specific autoantibodies are increasingly identified in dermatomyositis patients.
  • These autoantibodies show strong associations with specific clinical features and complications.

Purpose of the Study:

  • To review the clinical significance of five key dermatomyositis-specific autoantibodies.
  • To highlight the role of these autoantibodies in classifying dermatomyositis into distinct subsets.

Main Methods:

  • Literature review focusing on clinical studies of dermatomyositis-specific autoantibodies.
  • Analysis of correlations between autoantibody status and clinical manifestations.

Main Results:

  • Novel dermatomyositis-specific autoantibodies are frequently detected.
  • Autoantibodies like anti-Mi-2, anti-MDA5, anti-TIF1, anti-NXP2, and anti-SAE correlate with specific clinical phenotypes.
  • These include interstitial lung disease and malignancy, aiding in patient stratification.

Conclusions:

  • Dermatomyositis-specific autoantibodies are valuable diagnostic and prognostic tools.
  • These autoantibodies facilitate the classification of dermatomyositis into clinically relevant homogeneous subsets.
  • Understanding autoantibody profiles improves patient management and prediction of complications.