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Positive Surgical Margins in the 10 Most Common Solid Cancers
Ryan K Orosco1, Viridiana J Tapia1, Joseph A Califano1,2,3
1Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, CA, USA.
Scientific Reports
|April 11, 2018
Summary
Positive surgical margins (PSM) impact cancer treatment and outcomes. This study analyzed PSM rates across common US cancers, revealing varied trends over time, with some increasing and others declining.
Area of Science:
- Oncology
- Surgical Pathology
- Public Health
Background:
- Positive surgical margins (PSM) after cancer resection are linked to increased need for adjuvant therapies, impacting patient prognosis and healthcare costs.
- Understanding PSM rates is crucial for evaluating and improving surgical oncology practices.
Purpose of the Study:
- To compare positive surgical margin (PSM) rates for the ten most common solid malignancies in the United States.
- To analyze temporal trends in PSM rates between 1998-2002 and 2008-2012.
Main Methods:
- Utilized data from the National Cancer Data Base (NCDB) for over 10 million patients diagnosed between 1998 and 2012.
- Focused on 6.5 million patients with available surgical margin status, comparing PSM rates across two distinct time periods.
Main Results:
- Positive surgical margin (PSM) prevalence varied significantly by tumor type and grade.
- Ovarian and prostate cancers exhibited the highest PSM rates in women and men, respectively. Oral cavity tumors showed the highest PSM rates for both genders.
- Declining PSM rates were observed for breast and lung cancers, while increases were noted for bladder, colon and rectum, and kidney cancers.
Conclusions:
- Significant variations in positive surgical margin (PSM) rates exist across common US solid tumors.
- Temporal trends indicate both improvements and worsening outcomes in achieving negative surgical margins for different cancer types.
- This analysis highlights areas for targeted intervention to enhance surgical oncology care and optimize patient outcomes.
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