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Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Review and Preview01:13

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
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Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
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Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
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Updated: Feb 12, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
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Association Between Circular Stapler Diameter and Stricture Rates Following Gastrointestinal Anastomosis: Systematic

W Allen1,2, C I Wells1,2, M Greenslade1

  • 1Surgical Engineering Laboratory, Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.

World Journal of Surgery
|April 11, 2018
PubMed
Summary
This summary is machine-generated.

Using larger circular stapler sizes significantly reduces the risk of gastrointestinal (GI) anastomotic strictures. This finding highlights the importance of stapler selection in preventing complications after GI surgery.

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Vessel-sparing Excision and Primary Anastomosis
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Area of Science:

  • Gastroenterology
  • Surgical Innovation
  • Medical Device Technology

Background:

  • Anastomotic stricture is a frequent complication following gastrointestinal (GI) surgery.
  • Strictures negatively impact patient quality of life, leading to malnutrition and requiring further interventions.
  • The choice of surgical instrumentation, specifically circular stapler diameter, is a potential modifiable factor.

Purpose of the Study:

  • To systematically review and meta-analyze the association between circular stapler diameter and anastomotic stricture rates across the entire GI tract.
  • To quantify the impact of different stapler sizes on stricture formation.
  • To provide evidence-based recommendations for surgical practice.

Main Methods:

  • A comprehensive literature search was conducted across major databases (EMBASE, MEDLINE, Cochrane Library).
  • Studies reporting radiologically or endoscopically confirmed anastomotic strictures were included.
  • Pooled odds ratios (OR) were calculated using random-effects models to assess the relationship between stapler size and stricture risk.

Main Results:

  • Twenty-one studies involving esophageal, gastric, and lower GI anastomoses were analyzed.
  • Smaller circular stapler diameters were consistently associated with higher rates of anastomotic stricture.
  • Significant associations were observed in esophageal (e.g., 21 vs. 25 mm staplers, OR 4.39) and gastric anastomoses (e.g., 21 vs. 25 mm staplers, OR 3.12).

Conclusions:

  • Larger circular stapler sizes are strongly linked to a reduced risk of anastomotic stricture in the upper GI tract.
  • While a similar trend was observed in the lower GI tract, data were limited.
  • Optimizing circular stapler selection may be crucial for minimizing stricture formation in GI surgery.