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Updated: Feb 12, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Prognostic value of selected risk scales in patients with end-stage heart failure
Wioletta Szczurek, Bożena Szyguła-Jurkiewicz1, Michał W Zakliczyński
13rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland. bjurkiewicz@sum.edu.pl.
Insights
The Model for End-stage Liver Disease eXcluding INR (MELD-XI) score better predicts one-year mortality in heart transplant candidates than the Heart Failure Survival Score (HFSS). The Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) scale showed comparable predictive value to HFSS.
Area of Science:
- Cardiology
- Transplantation Medicine
- Medical Informatics
Background:
- Increasing orthotopic heart transplantation (OHT) waiting lists necessitate accurate patient risk stratification.
- Identifying high-risk patients is crucial for efficient OHT resource allocation.
Purpose of the Study:
- To assess the predictive accuracy of MELD-XI and MAGGIC scales for one-year mortality in OHT candidates.
- To compare the prognostic performance of MELD-XI and MAGGIC against the HFSS.
Main Methods:
- Retrospective review of 370 adult ambulatory patients awaiting OHT (2012-2016).
- Evaluation of MELD-XI, MAGGIC, and HFSS scoring systems.
- Analysis of one-year mortality rates and predictive performance using Area Under the Curve (AUC).
Main Results:
- Overall one-year mortality was 27.6%.
- MELD-XI demonstrated a higher AUC (0.812) compared to HFSS (0.781).
- MAGGIC (AUC 0.771) showed comparable predictive value to HFSS.
Conclusions:
- Elevated MELD-XI and MAGGIC scores, and lower HFSS scores, correlate with increased one-year mortality risk.
- MELD-XI offers superior prognostic utility over HFSS for OHT candidates.
- MELD-XI and MAGGIC scales are valuable tools for risk stratification in heart transplant evaluation.
Background:
Due to the increasing number of patients placed on waiting lists for orthotopic heart transplantation (OHT), the selection of patients with the highest risk of death has become paramount.
Aim:
This study aimed to evaluate the predictive value of the Model for End-stage Liver Disease eXcluding INR (MELD-XI) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) scales in ambulatory patients awaiting OHT and compare them to the Heart Failure Survival Score (HFSS).
Methods:
The study was a retrospective review of 370 adult ambulatory patients with end-stage heart failure, who were added to the OHT waiting list at our institution between 2012 and 2016.
Results:
The median age of the patients was 54.0 (46.0-60.0) years, and 324 (87.6%) of them were male. The overall one-year mortality was 27.6%. The areas under the curve (AUCs) for the MAGGIC and HFSS scales were comparable: 0.771 (95% confidence interval [CI] 0.720-0.823); sensitivity 77%, specificity 68% vs. 0.781 (95% CI 0.732-0.829); sensitivity 90%, specificity 58%, respectively. The AUC for the MELD-XI scale was higher than that for the HFSS scale: 0.812 (95% CI 0.769-0.856); sensitivity 91%, specificity 63% vs. 0.781 (95% CI 0.732-0.829) sensitivity 90%, specificity 58%, respectively.
Conclusions:
Our study demonstrated that elevated MELD-XI and MAGGIC scores and lowered HFSS scores were associated with an increased risk of death during one-year follow-up. The prognostic utility of the MELD-XI scoring system was better than that of the HFSS scale, while the MAGGIC scale was comparable to the HFSS.
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