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Solid nuclei and liquid droplets: A parallel treatment for 3 phase systems.

Frank A Ferrone1

  • 1Department of Physics, Drexel University, Philadelphia, Pennsylvania, 19010.

Protein Science : a Publication of the Protein Society
|April 11, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a new model for accelerated nucleation, where liquid and solid aggregate formation compete. This approach explains how labile liquid aggregates can switch to solid growth, speeding up crystallization even in unfavorable conditions.

Keywords:
kineticsliquid-liquid demixingnucleationprotein assembly

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Area of Science:

  • Physical Chemistry
  • Materials Science
  • Biophysics

Background:

  • Liquid-liquid demixing transitions accelerate solid-phase self-assembly.
  • Existing models do not fully capture accelerated nucleation dynamics.

Purpose of the Study:

  • To present a novel theoretical framework for accelerated nucleation.
  • To describe competing pathways for solid and liquid aggregate formation.
  • To apply a chemical potential formalism to nucleation processes.

Main Methods:

  • Modeling parallel pathways for solid and liquid aggregate formation.
  • Utilizing a chemical potential formalism.
  • Analyzing existing Lysozyme data.

Main Results:

  • Small, labile liquid aggregates can transition to solid growth.
  • Accelerated nucleation occurs even when the liquid-demixed state is unfavorable.
  • The effective nucleus size becomes concentration-independent in this model.

Conclusions:

  • The proposed model offers a new perspective on accelerated nucleation.
  • This formalism can be applied to various nucleation phenomena, including LLD processes.
  • The study provides a framework for understanding complex self-assembly mechanisms.