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Updated: Feb 12, 2026

Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
Published on: June 7, 2018
Insights into the Crystallization and Structural Evolution of Glycine Dihydrate by In Situ Solid-State NMR
Paolo Cerreia Vioglio1, Giulia Mollica1, Marie Juramy1
1Aix Marseille Univ, CNRS, ICR, Marseille, France.
Abstract:
In situ solid-state NMR spectroscopy is exploited to monitor the structural evolution of a glycine/water glass phase formed on flash cooling an aqueous solution of glycine, with a range of modern solid-state NMR methods applied to elucidate structural properties of the solid phases present. The glycine/water glass is shown to crystallize into an intermediate phase, which then transforms to the β polymorph of glycine. Our in situ NMR results fully corroborate the identity of the intermediate crystalline phase as glycine dihydrate, which was first proposed only very recently.
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