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Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
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Approaches for simplified HCV diagnostic algorithms.

Slim Fourati1, Jordan J Feld2, Stéphane Chevaliez1

  • 1Department of Virology, Henri Mondor Hospital, National Reference Center for Viral Hepatitis B, C and delta D, INSERMU955, Créteil, France.

Journal of the International AIDS Society
|April 11, 2018
PubMed
Summary
This summary is machine-generated.

Simplifying Hepatitis C virus (HCV) screening and diagnosis is essential for global elimination. Advances in rapid diagnostic testing and decentralized strategies are key to achieving the WHO

Keywords:
HCVdiagnosispoint-of-carerapid diagnostic testscreening

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Area of Science:

  • Hepatology
  • Public Health
  • Infectious Diseases

Background:

  • Global control of Hepatitis C virus (HCV) infection is feasible with advanced antiviral therapies.
  • Achieving the World Health Organization's (WHO) 90% diagnosis rate by 2030 requires simplified screening and diagnosis strategies.

Purpose of the Study:

  • To review strategies for simplifying HCV screening and diagnosis.
  • To identify key parameters for effective HCV elimination programs.

Main Methods:

  • Literature review of published and unpublished data (2008-2017).
  • Inclusion of expert consensus on point-of-care testing, rapid diagnostics, HCV core antigen, and dried blood spots.
  • Manual search for country-specific HCV elimination program data.

Main Results:

  • Development of reliable HCV core antigen tests and nucleic acid amplification technologies for decentralized settings.
  • One-step screening and diagnosis strategies can simplify algorithms in high prevalence areas if costs are reduced.
  • Genotyping may become unnecessary with the availability of pangenotypic antiviral therapy.

Conclusions:

  • Despite progress, the overall HCV diagnosis package remains too expensive for widespread implementation in low- and middle-income countries.
  • Efforts to reduce costs and implement reliable tests are crucial for a public health approach to HCV elimination.