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Testosterone Reduces Spinal Cord Injury-Induced Effects on Male Reproduction by Preventing CADM1 Defect

Hamid Choobineh1,2, Mahsa Kazemi3, Mohammad Ali Sadighi Gilani4

  • 1School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Cell Journal
|April 11, 2018
PubMed
Abstract

Insights

Testosterone treatment improved sperm parameters and testis function after spinal cord injury (SCI). Immediate testosterone administration was most effective, enhancing CADM1 expression and sperm quality in SCI mice.

Area of Science:

  • Reproductive biology
  • Neuroscience
  • Endocrinology

Background:

  • Spinal cord injury (SCI) can lead to significant reproductive dysfunction.
  • Testosterone plays a crucial role in male reproductive health.
  • CADM1 (cell adhesion molecule 1) is implicated in testicular function.

Purpose of the Study:

  • To investigate the impact of SCI on CADM1 expression and sperm parameters.
  • To evaluate the therapeutic effects of exogenous testosterone on SCI-induced reproductive deficits.
  • To determine the optimal timing for testosterone administration post-SCI.

Main Methods:

  • Experimental induction of SCI in mice.
  • Administration of exogenous testosterone at different time points post-SCI.
  • Quantification of CADM1 gene expression and protein immunoreactivity.
  • Assessment of sperm parameters and serum testosterone levels.

Main Results:

  • SCI caused abnormalities in sperm parameters and testicular architecture, with reduced CADM1 expression.
  • Testosterone treatment improved sperm parameters and compensated for reduced serum testosterone levels.
  • Immediate testosterone administration showed the most significant benefits, increasing CADM1 levels and improving sperm motility and testicular criteria.

Conclusions:

  • Exogenous testosterone can ameliorate reproductive dysfunction following SCI.
  • The beneficial effects of testosterone are linked to its influence on CADM1 expression and dynamics.
  • Prompt intervention with testosterone post-SCI is recommended for optimal recovery of reproductive function.
Keywords:
Cell Adhesion MoleculeSpermSpinal Cord InjuryTestisTestosterone

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