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Lactobacillus fermentum UCO-979C strongly inhibited Helicobacter pylori SS1 in Meriones unguiculatus

J S Merino1, A García1, E Pastene2

  • 11 Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, 4030000 Concepción, Chile.

Beneficial Microbes
|April 11, 2018
PubMed

Insights

Researchers found that Lactobacillus fermentum UCO-979C significantly inhibited Helicobacter pylori colonization in gerbils. This human gastric probiotic shows strong potential for combating this common, high-priority pathogen.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Probiotics

Background:

  • Helicobacter pylori is a high-priority pathogen with increasing prevalence.
  • Developing effective bacterial probiotics against H. pylori remains a clinical challenge.

Purpose of the Study:

  • To evaluate the in vivo anti-H. pylori efficacy of the human gastric probiotic strain Lactobacillus fermentum UCO-979C.
  • To assess the protective activity of L. fermentum UCO-979C against H. pylori colonization in a Mongolian gerbil model.

Main Methods:

  • A Mongolian gerbil model (Meriones unguiculatus) was employed.
  • Animals were administered L. fermentum UCO-979C and/or H. pylori SS1.
  • H. pylori colonization levels in the antrum were quantified to assess probiotic activity.

Main Results:

  • Lactobacillus fermentum UCO-979C demonstrated significant inhibition of H. pylori SS1 colonization.
  • A reduction of up to 87% in gastric antrum colonization by H. pylori was observed.
  • The probiotic strain showed strong anti-H. pylori activity in vivo.

Conclusions:

  • Lactobacillus fermentum UCO-979C exhibits potent probiotic properties against Helicobacter pylori.
  • This strain is a promising candidate for further development as a therapeutic agent against H. pylori infections.
Keywords:
Helicobacter pyloriLactobacillus fermentumMongolian gerbilsanimal modelsprobiotics

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