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Updated: Feb 12, 2026

Expansion and Enrichment of Gamma-Delta γδ T Cells from Apheresed Human Product
Published on: September 22, 2021
Organocatalytic Asymmetric Domino Michael/Acyl Transfer Reaction between γ/δ-Hydroxyenones and α-Nitroketones
Keshab Mondal1, Subhas Chandra Pan1
1Department of Chemistry , Indian Institute of Technology Guwahati , North Guwahati , Assam 781039 , India.
Abstract:
An organocatalytic asymmetric domino Michael/acyl transfer reaction has been developed between γ/δ-hydroxyenones and α-nitroketones. Cinchona alkaloid derived bifunctional amino-squaramide catalysts were found to be the best catalysts for this reaction. The products having nitro, keto, and ester functionalities were obtained in high yields and with excellent enantioselectivities, and also a few synthetic transformations have been demonstrated.
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