Mycoplasma-induced pustulosis with perifollicular involvement

Area of Science:

• Dermatology
• Infectious Diseases
• Pediatrics

Background:

• Mycoplasma pneumoniae-induced rash and mucositis (MIRM) is a clinical syndrome involving mucosal and skin lesions.
• Commonly reported skin manifestations include vesiculobullous, targetoid, papular, macular, and morbilliform eruptions.

Observation:

• A 13-year-old boy presented with a pustular skin eruption.
• This presentation is exceptionally rare in MIRM, with only one prior report in the literature.

Findings:

• This is the second reported case of MIRM presenting with pustulosis.
• Histopathologic examination revealed perifollicular neutrophilic infiltration, a novel finding for MIRM.

Implications:

• This case expands the spectrum of cutaneous manifestations of MIRM.
• Understanding these histopathologic findings may aid in diagnosing and managing MIRM, particularly atypical presentations.