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Updated: Feb 12, 2026
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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An amelanotic nail bed melanoma presenting as persistent onychodystrophy
Lisa Ishii1, Nicholas A Richmond, Stephanie J Carstens
1Medical College of Georgia at Augusta University, Augusta, Georgia. lishii@augusta.edu.
Dermatology Online Journal
|April 11, 2018
Summary
Amelanotic melanoma of the nail apparatus is rare and challenging to diagnose, often mimicking nail dystrophy. Early detection is crucial for better outcomes in this aggressive cancer.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Nail apparatus melanomas are uncommon malignancies.
- The amelanotic subtype presents diagnostic challenges.
- Delayed diagnosis is associated with poor prognosis.
Observation:
- A 69-year-old man presented with subungual amelanotic melanoma.
- The melanoma mimicked persistent nail dystrophy and was initially treated for onychomycosis.
- Diagnosis was delayed due to the unusual presentation.
Findings:
- The patient was diagnosed with subungual amelanotic melanoma.
- Treatment involved partial amputation of the left thumb to minimize recurrence risk.
Implications:
- Highlights the importance of considering melanoma in persistent nail dystrophies.
- Emphasizes the need for heightened clinical suspicion for amelanotic melanoma.
- Underscores the impact of delayed diagnosis on treatment and prognosis.
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