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Updated: Feb 12, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Synthesis of triblock copolymeric micelle based on poly (ethylene glycol) and poly (vinyl acetate) through reversible
1Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad 826004, India.
Hypothesis:
Polymeric micelles are fabricated by the self-aggregation of amphiphilic polymers in aqueous medium. Amphiphilic block copolymers consist of hydrophobic and hydrophilic blocks. The hydrophilic blocks form corona, while hydrophobic blocks produce core of the micelle.
Experiments:
In the present manuscript, a triblock copolymer derived from poly (ethylene glycol) and poly (vinyl acetate) (PVAc-b-PEG200-b-PVAc) has been prepared via reversible addition-fragmentation chain transfer polymerization. Its structural properties as well as micellar stability have been studied and application as dye carrier has been discussed in details.
Findings:
The GPC analysis shows the low polydispersity of the developed copolymer that signifies the controlled nature of polymerization. The copolymer demonstrates long-term micellar stability, which has been determined by dynamic light scattering (DLS) analysis. The block copolymer reveals excellent pH-triggered release behavior of loaded Nile red, which ascertained the dye carrier feature of PVAc-b-PEG200-b-PVAc.
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