Related Experiment Video
Updated: Feb 12, 2026

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
Published on: July 1, 2018
GntR is involved in the expression of virulence in strain Streptococcus suis P1/7
Ying Zhou1, Ruonan Nie1, Xiaoyue Liu1
1Key Laboratory of Environment Correlative Dietology, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, People's Republic of China.
Abstract:
Streptococcus suis is a severe zoonotic pathogen, responsible for acute diseases in pigs and human. GntR proteins are widely distributed in various bacterial species. In a previous study, GntR proteins were reported to be involved in virulence in many pathogens. To investigate the relationship between GntR and S. suis serotype 2, we constructed an isogenic deletion mutant P1/7ΔgntR and an isogenic single-nucleotide substitution mutant P1/7gntR(SC070731), which took strain P1/7 as parent. The results show that the mutants P1/7ΔgntR and P1/7gntR(SC070731) have a stronger ability to tolerate oxidative stress and to reproduce in blood. Moreover, a higher fatality rate was observed in mice when challenged with P1/7ΔgntR or P1/7gntR(SC070731) compared with that of P1/7. Overall, all results suggest that GntR greatly impacts the virulence of S. suis serotype 2 strain P1/7 and give a new perspective on virulence generation in S. suis.
Related Concept Videos
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...
Thermal Strain
Shearing Strain
Measurements of Strain
Strain Energy
Consider a rod that is fixed at one end and subjected to an axial force at the free end. This axial force induces stress within the rod, leading to its elongation. As the axial force increases, so does the elongation of the rod, illustrating a direct relationship between the force applied and the resulting...
Problem Solving on Stress and Strain

