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Updated: Feb 12, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

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Published on: December 14, 2020

[Laryngopharyngeal Reflux].

Rudolf Reiter¹, Adrienne Heyduck¹, Thomas Seufferlein²

¹Univ.-Klinik Ulm Sektion Phoniatrie und Pädaudiologie der Universitätsklinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie.

Laryngo- Rhino- Otologie

|April 11, 2018

Summary

This summary is machine-generated.

Laryngopharyngeal reflux (LPR) affects 31% of people and often causes hoarseness and throat clearing. Diagnosis relies on symptoms and laryngoscopy, with treatment involving lifestyle changes and medication.

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Area of Science:

Otolaryngology
Gastroenterology

Background:

Laryngopharyngeal reflux (LPR) has a high prevalence of 31% in the general population.
LPR is associated with laryngeal diseases like chronic laryngitis and contact granuloma in up to 50% of patients.
The role of LPR in glottic carcinoma development remains unclear, and evidence-based diagnostic data is lacking.

Purpose of the Study:

To review the clinical diagnosis and treatment of LPR.
To highlight the diagnostic challenges and multimodal therapeutic approaches for LPR.

Main Methods:

Clinical diagnosis based on symptoms (hoarseness, chronic cough, throat clearing, dysphagia) and laryngoscopic findings (erythema, hyperplasia, edema).
Pharyngeal 24-hour pH-monitoring as an occasional confirmatory method.
Multimodal therapy including dietary changes, proton pump inhibitors (PPIs), and surgical intervention when necessary.

Main Results:

LPR is commonly diagnosed clinically due to the absence of definitive evidence-based diagnostic criteria.
Symptoms include hoarseness, chronic cough, throat clearing, globus pharyngis, and dysphagia.
Laryngoscopic findings may include mucosal erythema, hyperplasia, and vocal cord edema.

Conclusions:

LPR diagnosis is primarily clinical, combining symptoms and laryngoscopic evidence.
Treatment is multimodal, often involving PPIs in collaboration with ENT and gastroenterology specialists.
Further research is needed to clarify LPR's role in glottic carcinoma and establish evidence-based diagnostic standards.