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Transparency in ovarian cancer clinical trial results: ClinicalTrials.gov versus PubMed, Embase and Google scholar

Anna Roberto1, Silvia Radrezza2, Paola Mosconi2

  • 1Laboratory for medical research and consumer involvement, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via G. La Masa 19, 20156, Milan, Italy. anna.roberto@marionegri.it.

Journal of Ovarian Research
|April 12, 2018
PubMed
Abstract

Insights

Transparency in clinical research is lacking, especially for ovarian cancer trials. Results from completed studies were often not published, impacting research credibility and patient trust.

Area of Science:

  • Oncology
  • Clinical Research
  • Medical Informatics

Background:

  • Transparency in clinical research is a growing concern among stakeholders.
  • Ovarian cancer research faces challenges due to disappointing treatment outcomes.
  • Assessing the availability and publication of clinical trial results is crucial.

Purpose of the Study:

  • To evaluate the public availability of results for ovarian cancer clinical trials on ClinicalTrials.gov.
  • To determine the frequency of non-publication of results in ClinicalTrials.gov, PubMed, Embase, and Google Scholar.

Main Methods:

  • Identified "completed status" ovarian cancer trials from ClinicalTrials.gov as of January 17, 2017.
  • Collected 752 completed trials, focusing on those closed between 2008 and 2015 (excluding Phase I).
  • Checked for result availability on ClinicalTrials.gov and searched major databases for published manuscripts.

Main Results:

  • Only 35% of eligible completed ovarian cancer trials had results posted on ClinicalTrials.gov.
  • Publication rates in PubMed, Embase, or Google Scholar ranged from 57.9% to 69.7% for completed studies.
  • A significant proportion of clinical trial results remain inaccessible to the public.

Conclusions:

  • The study highlights a concerning lack of transparency and credibility in clinical research.
  • Improved publication and dissemination of clinical study results are essential.
  • Patient representatives and the medical community should advocate for greater research transparency.
Keywords:
Clinical trialsClinicalTrials.govOvarian cancerPublication of resultsTransparency

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