Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Language Development01:22

Language Development

936
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
936
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.2K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.2K
Development of Immunocompetence01:22

Development of Immunocompetence

987
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
987
Development of the Heart01:27

Development of the Heart

2.7K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
2.7K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.4K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reproductive outcomes of women aged 40 and older undergoing IVF with donor sperm.

Human reproduction (Oxford, England)·2021
Same author

Reply: Individualization of ovarian stimulation to safely optimize cycle outcomes.

Human reproduction (Oxford, England)·2020
Same author

No effect of ovarian stimulation and oocyte yield on euploidy and live birth rates: an analysis of 12 298 trophectoderm biopsies.

Human reproduction (Oxford, England)·2020
Same author

A comparison of morphokinetic markers predicting blastocyst formation and implantation potential from two large clinical data sets.

Journal of assisted reproduction and genetics·2019
Same author

A treatment algorithm for couples with unexplained infertility based on sperm chromatin assessment.

Journal of assisted reproduction and genetics·2018
Same author

A rationale for biopsying embryos reaching the morula stage on Day 6 in women undergoing preimplantation genetic testing for aneuploidy.

Human reproduction (Oxford, England)·2018
Same journal

Mitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.

Reproduction (Cambridge, England)·2026
Same journal

Spatial Transcriptomics in Ovarian Biology Technologies, Computational Challenges, and Biological Insights.

Reproduction (Cambridge, England)·2026
Same journal

Toll-like Receptor 4 Knockout Mice are Protected Against PMOS-like Pathogenesis.

Reproduction (Cambridge, England)·2026
Same journal

Evidence That Heat Shock Protein A5 (HSPA5) Plays a Role During Bovine In Vitro Embryo Production.

Reproduction (Cambridge, England)·2026
Same journal

The use of isoflurane to cause multiple large Ca2+ transients in mouse eggs.

Reproduction (Cambridge, England)·2026
Same journal

Fibroblast Growth Factor 9 Promotes Rat Leydig Cell Development via H3K4me3 Histone Modifications.

Reproduction (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.9K

Development of ICSI.

C L O'Neill1, S Chow1, Z Rosenwaks1

  • 1The Ronald O. Perelman and Claudia Cohen Center for Reproductive MedicineWeill Cornell Medicine, New York, New York, USA.

Reproduction (Cambridge, England)
|April 12, 2018
PubMed
Summary
This summary is machine-generated.

Intracytoplasmic sperm injection (ICSI) revolutionized assisted reproduction by overcoming fertilization failure. This technique consistently achieves fertilization and higher pregnancy rates, becoming the preferred method for male infertility.

More Related Videos

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.2K
Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.7K

Related Experiment Videos

Last Updated: Feb 12, 2026

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
07:23

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications

Published on: October 20, 2023

1.9K
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.2K
Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.7K

Area of Science:

  • Reproductive Medicine
  • Embryology
  • Andrology

Background:

  • Assisted reproductive techniques (ART) emerged following the first successful in vitro fertilization.
  • Complete fertilization failure was a significant challenge, particularly in cases of male infertility.
  • Early ART faced limitations in achieving consistent fertilization outcomes.

Purpose of the Study:

  • To review the development and impact of Intracytoplasmic Sperm Injection (ICSI) in overcoming fertilization challenges.
  • To highlight ICSI's role in improving pregnancy rates in assisted reproduction.
  • To discuss the established indications and future applications of ICSI.

Main Methods:

  • Review of historical data and clinical outcomes related to ICSI.
  • Analysis of ICSI's efficacy compared to previous fertilization techniques.
  • Examination of ICSI's application across various male infertility scenarios.

Main Results:

  • ICSI enables a 1:1 gamete ratio, ensuring consistent fertilization.
  • The technique provides higher pregnancy rates compared to earlier methods.
  • ICSI is effective with both ejaculated and surgically retrieved spermatozoa, regardless of semen parameters.

Conclusions:

  • ICSI has become the most popular and reliable insemination method globally.
  • Its success in treating male factor infertility is well-established.
  • ICSI is poised for continued use in advanced reproductive technologies like in vitro spermatogenesis.