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Related Concept Videos

Integrins01:10

Integrins

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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
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Activation of Integrins01:15

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Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
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Metallic Solids02:37

Metallic Solids

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Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
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Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Molecular and Ionic Solids02:54

Molecular and Ionic Solids

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Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
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Network Covalent Solids02:18

Network Covalent Solids

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Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
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Related Experiment Video

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Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
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Prognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis.

Quanwu Sun1, Chuan Zhou2, Ruofei Ma3

  • 1Department of Breast Surgery, The People's Hospital of Gansu Province, Lanzhou City, Gansu, China.

Oncotargets and Therapy
|April 12, 2018
PubMed
Summary

Integrin-beta 1 (ITGB1) expression impacts survival in lung and breast cancers, but its prognostic value varies across solid tumors. This meta-analysis clarifies ITGB1's role in cancer prognosis.

Keywords:
ITGB1meta-analysisprognosissolid cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Integrin-beta 1 (ITGB1) exhibits altered expression in solid tumors, yet its prognostic significance is debated.
  • Understanding ITGB1's role is crucial for accurate cancer prognosis and potential therapeutic strategies.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the correlation between ITGB1 expression and overall survival (OS) in solid cancers.
  • To assess the relationship between ITGB1 expression and clinicopathological characteristics across various solid tumor types.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Web of Science databases up to June 1, 2017.
  • Inclusion of 22 studies comprising 3,666 patients with lung, colorectal, breast, melanoma, and pancreatic cancers.
  • Meta-analysis and sensitivity analysis to determine the pooled hazard ratios (HR) for OS and disease-free survival.

Main Results:

  • High ITGB1 expression correlated with worse OS in lung cancer (HR=1.78) and breast cancer (HR=1.88).
  • High ITGB1 expression was associated with poorer disease-free survival in breast cancer (HR=1.63) and pancreatic cancer (HR=2.49).
  • No significant association between high ITGB1 expression and OS was found in colorectal cancer, pancreatic cancer, or melanoma.

Conclusions:

  • ITGB1 expression has a significant prognostic value for overall survival in lung and breast cancers.
  • The prognostic implications of ITGB1 expression differ across various solid tumor types, highlighting a complex role.
  • The study confirms the robustness of pooled results, underscoring the variable prognostic value of ITGB1 in solid cancers.