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Updated: Feb 12, 2026

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
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Functional role of microRNA-135a in colitis

Chunyan Lou1, Yanyang Li1

  • 1Department of Pediatrics, Huaihe Hospital of Henan University, No. 8, Baobei Road, Gulou District, Kaifeng, 475000 China.

Journal of Inflammation (London, England)
|April 12, 2018
PubMed
Abstract

Insights

MicroRNA-135a (miR-135a) is suppressed in inflammatory bowel disease (IBD). Upregulating miR-135a inhibits colon cell apoptosis and inflammation, suggesting a therapeutic role for IBD.

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Oncology

Background:

  • Inflammatory bowel disease (IBD) is linked to increased colon cancer risk.
  • Apoptosis and inflammation are key factors in IBD development.
  • MicroRNAs (miRNAs) are implicated in the etiology of various diseases, including IBD.

Purpose of the Study:

  • To investigate the role of miR-135a in the pathogenesis of colitis.
  • To explore miR-135a's potential as a therapeutic target in inflammatory bowel disease.

Main Methods:

  • Utilized a murine model of DSS-induced colitis.
  • Assessed miR-135a expression in colonic cells.
  • Manipulated miR-135a levels and Hif1α expression to evaluate effects on apoptosis and inflammation.

Main Results:

  • miR-135a expression was found to be suppressed in colonic cells of the colitis model.
  • Upregulating miR-135a significantly inhibited apoptosis and inflammation in colonic epithelial cells.
  • Hif1α was identified as a direct target of miR-135a; its knockdown suppressed apoptosis and inflammation.

Conclusions:

  • Overexpression of miR-135a demonstrates anti-apoptotic and anti-inflammatory effects in vitro.
  • miR-135a holds potential as a therapeutic agent for inflammatory bowel disease.
Keywords:
Hif1αInflammatory bowel diseaseMurine model of DSS-induced colitismiR-135a

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