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Calcium function in affective disorders and healthy controls.

C L Bowden1, L G Huang, M A Javors

  • 1Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284-7792.

Biological Psychiatry
|February 15, 1988
PubMed
Summary
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This study reveals distinct calcium metabolism disturbances in affective disorders. Unipolar and bipolar patients show differing calcium levels and cellular functions, suggesting unique pathophysiological pathways.

Area of Science:

  • Neurobiology
  • Biochemistry
  • Psychiatry

Background:

  • Altered calcium metabolism is implicated in affective disorders.
  • Understanding these disturbances is crucial for identifying pathophysiological differences.

Purpose of the Study:

  • To investigate calcium metabolism across different affective disorder subtypes (unipolar, bipolar, manic) and healthy controls.
  • To compare extracellular and intracellular calcium measures, including cellular calcium handling capabilities.

Main Methods:

  • Assessed plasma calcium, platelet intracellular calcium concentration.
  • Measured red blood cell (RBC) and platelet calcium adenosine triphosphatase (ATPase) activity and calcium uptake.
  • Correlated calcium measures with illness severity in unipolar and bipolar depressed patients.

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Main Results:

  • Lower plasma calcium observed in unipolar and manic patients compared to controls.
  • Unipolar patients exhibited lower platelet calcium concentration than bipolar patients.
  • RBC Ca++ ATPase was lower in unipolar/control subjects versus bipolar/manic patients.
  • Platelet Ca++ ATPase and uptake correlated inversely with illness severity in unipolar patients; similar correlations found for RBC Ca++ ATPase and platelet Ca++ uptake in bipolar depressed patients.

Conclusions:

  • Affective disorders are associated with significant calcium metabolism abnormalities.
  • Distinct differences in calcium measures between unipolar and bipolar patients suggest divergent pathophysiological mechanisms.
  • Calcium dysregulation may play a key role in the distinct clinical presentations of unipolar and bipolar disorders.