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Updated: Feb 12, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Successful treatment of refractory TAFRO syndrome with elevated vascular endothelial growth factor using thyroxine
Satoko Oka1, Kazuo Ono2, Masaharu Nohgawa1
1Division of Hematology Japanese Red Cross Society Wakayama Medical Center Wakayama Japan.
Abstract:
Although the clinical significance of hypothyroidism in TAFRO syndrome is unknown, vascular endothelial growth factor (VEGF) levels decreased with improvements in the condition of our refractory TAFRO cases after thyroxine supplement therapy. Our results indicate that elevated VEGF levels are a potential factor in the pathogenesis and anasarca of TAFRO syndrome with hypothyroidism.
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