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Updated: Feb 12, 2026

Measuring Pressure Volume Loops in the Mouse
Published on: May 2, 2016
Observational study of laryngoscopy plus flow-volume loops during exercise
Paolo T Pianosi1, Diana M Orbelo2, Shelagh A Cofer2
1Department of Pediatric & Adolescent Medicine Mayo Clinic 200 First St. SW Rochester Minnesota 55905.
Abstract:
Laryngoscopy is the gold standard to diagnose exercise-induced laryngeal obstruction, though inspiratory flow-volume loop may provide a clue. We combined tidal flow-volume loop analysis plus laryngoscopy during exercise and found that cigar-shaped - not flattened - inspiratory loops are associated with obstruction. Pursed-lip breathing slows inhalation thereby reducing vocal fold adduction.
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