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Plasma citrate concentration: a possible biomarker for glaucoma in children

Marta Michalczuk1, Porowski Tadeusz2, Beata Urban1

  • 1Department of Paediatric Ophthalmology and Strabismus, Medical University of Białystok, Białystok, Poland.

BMJ Paediatrics Open
|April 12, 2018
PubMed

Insights

Plasma citrate levels may indicate glaucoma in children. This study found lower plasma citrate in children with glaucoma compared to healthy peers, suggesting its potential as a diagnostic biomarker.

Area of Science:

  • Ophthalmology
  • Biochemistry
  • Pediatrics

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Early detection and diagnosis are crucial for managing glaucoma, especially in pediatric populations.
  • Biomarkers for glaucoma diagnosis are actively being researched.

Purpose of the Study:

  • To investigate the potential of plasma and urine citrate levels as biomarkers for glaucoma in school-aged children.
  • To compare citrate levels in children diagnosed with glaucoma versus a healthy control group.

Main Methods:

  • The study included 34 school-aged children with glaucoma and 34 age-matched healthy controls.
  • Plasma and urine citrate levels were measured in both groups.
  • Statistical analysis, including the Kruskal-Wallis test, was used for comparison.

Main Results:

  • Plasma citrate concentrations were significantly lower in children with glaucoma compared to the control group (p=0.0036).
  • No statistically significant differences were found in urine citrate levels or urine citrate to creatine ratio between the groups.
  • These findings suggest a specific role for plasma citrate.

Conclusions:

  • Plasma citrate concentration may serve as a potential biomarker for glaucoma in the pediatric population.
  • Further research is warranted to validate plasma citrate as a reliable glaucoma indicator in children.
Abstract

Keywords:
Ophthalmologyscreening

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