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[Paraneoplastic syndromes in rheumatology]
1Zentrum Innere Medizin, Medizinische Klinik und Poliklinik II, Rheumatologie/Klinische Immunologie, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland. Schmalzing_M@ukw.de.
Zeitschrift Fur Rheumatologie
|April 12, 2018
Summary
Rheumatic paraneoplastic syndromes are rare but indicate underlying cancer. Early diagnosis and treatment of the malignancy are crucial for managing these inflammatory conditions.
Area of Science:
- Rheumatology
- Oncology
- Internal Medicine
Background:
- Rheumatic paraneoplastic syndromes are a group of disorders associated with cancer.
- These syndromes include various forms of arthritis, fasciitis, synovitis, panniculitis, vasculitis, myositis, and osteoarthropathy.
- Their recognition is vital for early cancer detection.
Purpose of the Study:
- To present the typical clinical manifestations, pathogenesis, prognosis, and treatment of rheumatic paraneoplastic syndromes.
- To emphasize the importance of timely diagnosis of underlying malignant diseases for improved patient outcomes.
- To outline a diagnostic strategy for suspected paraneoplastic rheumatic symptoms.
Main Methods:
- Review of clinical manifestations, pathogenesis, prognosis, and treatment of rheumatic paraneoplastic syndromes.
- Discussion of diagnostic approaches for suspected paraneoplastic rheumatic symptoms.
- Emphasis on the role of curative removal of malignant disease.
Main Results:
- Rheumatic paraneoplastic syndromes encompass a range of inflammatory conditions linked to cancer.
- Conventional treatments like corticosteroids and NSAIDs are often insufficient.
- Successful management hinges on the curative removal of the underlying malignancy.
Conclusions:
- Prompt identification of rheumatic paraneoplastic syndromes can lead to earlier cancer diagnosis and potentially higher cure rates.
- A step-wise diagnostic strategy is recommended when paraneoplastic etiology is suspected.
- Effective treatment relies on addressing the primary cancer, not just the rheumatic symptoms.
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