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Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
Published on: January 21, 2020
Advances in Ureteral Stent Design and Materials
Ali Mosayyebi1,2, Costantino Manes3, Dario Carugo4,5
1Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK. a.mosayyebi@soton.ac.uk.
Advancements in stent materials, design, and coatings are crucial for ideal stent performance. Recent focus on flow dynamics may revolutionize future ureteric stent designs to prevent encrustation and biofilm formation.
Area of Science:
- Biomaterials Science
- Medical Device Engineering
- Urology
Background:
- Stent performance is critically influenced by material, design, and surface coating.
- Ureteric stents are prone to encrustation and biofilm formation, leading to failure.
Purpose of the Study:
- To review fundamental developments in stent material, design, and surface coating.
- To identify key technological advancements contributing to the ideal stent.
- To explore the impact of flow dynamics on stent performance and failure modes.
Main Methods:
- Literature review of recent advancements in ureteric stent technology.
- Analysis of material, design, and surface coating innovations.
- Examination of flow dynamic performance and its relation to stent failure.
Main Results:
- Significant progress has been made in stent materials, designs, and surface coatings.
- Flow dynamic performance is increasingly recognized as vital for stent function.
- Local flow fields correlate with crystal and microorganism deposition, impacting stent performance.
Conclusions:
- Technological developments in materials, designs, and coatings are essential for improving stent performance.
- Understanding and optimizing flow dynamics can revolutionize future ureteric stent designs.
- Addressing encrustation and biofilm formation through material, design, and coating innovations is key to preventing stent failure.
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Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.

