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Updated: Feb 12, 2026
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In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
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Cerebrovascular Events After Continuous-Flow Left Ventricular Assist Devices
Pouya Tahsili-Fahadan1,2, David R Curfman3, Albert A Davis3
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neurocritical Care
|April 12, 2018
Summary
Cerebrovascular events (CVEs) are common after continuous-flow left ventricular assist device (CF-LVAD) implantation, increasing mortality. Optimal stroke prevention strategies for these patients require further investigation.
Area of Science:
- Cardiology
- Neurology
- Medical Devices
Background:
- Cerebrovascular events (CVEs) are a significant complication following continuous-flow left ventricular assist device (CF-LVAD) implantation.
- Understanding CVE incidence, risk factors, and outcomes is crucial for patient management.
Purpose of the Study:
- To investigate the incidence, subtypes, and risk factors of CVEs after CF-LVAD implantation.
- To evaluate the impact of CVEs on patient outcomes, including mortality and heart transplantation rates.
Main Methods:
- Retrospective analysis of clinical and neuroimaging data from 372 CF-LVAD patients (May 2005 - December 2013).
- Statistical methods were employed to identify risk factors and outcome associations.
Main Results:
- CVEs occurred in 19% of patients, with ischemic and hemorrhagic types being most common.
- Risk factors included history of coronary artery disease and female gender for ischemic CVEs, and diabetes mellitus for hemorrhagic CVEs.
- CVE occurrence was linked to increased mortality, while heart transplantation improved survival.
Conclusions:
- CF-LVAD implantation is associated with high CVE rates and increased mortality.
- Further research is needed to establish optimal stroke prevention strategies in the post-LVAD population.
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