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Cerebrovascular Events After Continuous-Flow Left Ventricular Assist Devices

Pouya Tahsili-Fahadan1,2, David R Curfman3, Albert A Davis3

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Neurocritical Care
|April 12, 2018
PubMed

Insights

Cerebrovascular events (CVEs) are common after continuous-flow left ventricular assist device (CF-LVAD) implantation, increasing mortality. Optimal stroke prevention strategies for these patients require further investigation.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Devices

Background:

  • Cerebrovascular events (CVEs) are a significant complication following continuous-flow left ventricular assist device (CF-LVAD) implantation.
  • Understanding CVE incidence, risk factors, and outcomes is crucial for patient management.

Purpose of the Study:

  • To investigate the incidence, subtypes, and risk factors of CVEs after CF-LVAD implantation.
  • To evaluate the impact of CVEs on patient outcomes, including mortality and heart transplantation rates.

Main Methods:

  • Retrospective analysis of clinical and neuroimaging data from 372 CF-LVAD patients (May 2005 - December 2013).
  • Statistical methods were employed to identify risk factors and outcome associations.

Main Results:

  • CVEs occurred in 19% of patients, with ischemic and hemorrhagic types being most common.
  • Risk factors included history of coronary artery disease and female gender for ischemic CVEs, and diabetes mellitus for hemorrhagic CVEs.
  • CVE occurrence was linked to increased mortality, while heart transplantation improved survival.

Conclusions:

  • CF-LVAD implantation is associated with high CVE rates and increased mortality.
  • Further research is needed to establish optimal stroke prevention strategies in the post-LVAD population.
Abstract

Keywords:
Cardiac transplantHeart failureLeft ventricular assist deviceStroke

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