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A ternary nanofibrous scaffold potential for central nerve system tissue engineering.

Niloufar Saadatkish1, Saied Nouri Khorasani1, Mohammad Morshed2

  • 1Department of Chemical Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.

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|April 12, 2018
PubMed
Summary

This study developed a polycaprolactone/gelatin/fibrinogen nanofibrous scaffold for tissue engineering. Higher fibrinogen content enhanced cell proliferation but reduced mechanical strength, indicating potential for nerve tissue regeneration.

Keywords:
electrospinningfibrinogengelatinpolycaprolactonetissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Developing advanced scaffolds is crucial for tissue engineering.
  • Polycaprolactone (PCL) offers mechanical strength, while gelatin and fibrinogen enhance hydrophilicity and cell interactions.
  • Ternary nanofibrous scaffolds combining these materials show promise for improved biological performance.

Purpose of the Study:

  • To develop and characterize a novel ternary polycaprolactone (PCL)/gelatin/fibrinogen nanofibrous scaffold.
  • To investigate the effect of varying fibrinogen content on scaffold properties and cell proliferation.
  • To evaluate the potential of this scaffold for tissue engineering applications, particularly in the central nervous system.

Main Methods:

  • Fabrication of PCL/gelatin/fibrinogen nanofibrous scaffolds with varying fibrinogen concentrations.
  • Morphological and chemical characterization using techniques like scanning electron microscopy and Fourier-transform infrared spectroscopy.
  • Mechanical testing (tensile tests) and assessment of hydrophilicity via water droplet contact angle measurements.
  • In vitro evaluation of cell-scaffold interaction using adipose-derived stem cells, including cell proliferation assays.

Main Results:

  • Nanofibers exhibited smooth morphology with reduced diameter upon fibrinogen incorporation.
  • Chemical characterization confirmed no adverse reactions between scaffold components.
  • Increased fibrinogen content decreased mechanical properties but significantly enhanced cell proliferation and hydrophilicity.
  • Statistical analysis confirmed significant differences in water contact angle and cell culture results.

Conclusions:

  • The developed PCL/gelatin/fibrinogen nanofibrous scaffold demonstrates tunable properties for tissue engineering.
  • Optimizing fibrinogen content can balance mechanical integrity with enhanced cell response.
  • This scaffold holds significant potential for applications in tissue regeneration, including central nervous system repair.