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Fruit Wines Inhibitory Activity Against α-Glucosidase
Uros Cakar1, Nada Grozdanic2, Aleksandar Petrovic3
1University of Belgrade,Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade, Serbia.
Current Pharmaceutical Biotechnology
|April 12, 2018
Summary
Blueberry wine shows significant potential for managing type 2 diabetes by inhibiting alpha-glucosidase. This fruit wine may help control postprandial hyperglycemia, offering a natural approach to diabetes management.
Area of Science:
- Food Science
- Biochemistry
- Pharmacology
Background:
- Fruit wines possess health-promoting properties, including enzyme modulation.
- Potential preventive role in diabetes mellitus and other chronic diseases.
Purpose of the Study:
- Evaluate the alpha-glucosidase inhibitory activity of various fruit wines.
- Investigate blueberry, black chokeberry, blackberry, raspberry, and sour cherry wines.
Main Methods:
- Fruit wines were prepared, with some samples having sugar added to pomace to increase alcohol and phenolic extraction.
- Alpha-glucosidase inhibitory activity was assessed and compared to acarbose.
- Molecular docking was used to study the binding energy of key compounds.
Main Results:
- All fruit wines demonstrated higher alpha-glucosidase inhibition than acarbose.
- Blueberry wine exhibited the most potent inhibition (IC50 = 24.14 µg/mL with sugar, 46.39 µg/mL without).
- Chlorogenic acid was the primary contributor to inhibition; ellagic acid had a lesser effect.
Conclusions:
- Blueberry wine is a promising candidate for medicinal food targeting early-stage type 2 diabetes.
- Further research is needed to confirm its therapeutic potential for controlling postprandial hyperglycemia.
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