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Related Experiment Video

Updated: Feb 12, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

ACP5: Its Structure, Distribution, Regulation and Novel Functions.

Xin Ren^1,2, Wen-Hua Shan¹, Lu-Lu Wei³

¹Jiangsu Key Laboratory of Biological Cancer Therapy Xuzhou Medical University, Xuzhou 221002, China.

Anti-Cancer Agents in Medicinal Chemistry

|April 12, 2018

Summary

Tartrate-resistant acid phosphatase 5 (ACP5) is crucial for bone health and macrophage function. This protein also plays a role in genetic diseases and cancer progression, highlighting its potential as a therapeutic target.

Keywords:

ACP5 NFATc1 c-Fos cancer genetic diseases phosphatase activity regulating factors.

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Area of Science:

Biochemistry
Molecular Biology
Pathology

Background:

Tartrate-resistant acid phosphatase 5 (ACP5) is a conserved protein with diverse roles.
ACP5 influences reactive oxygen species, bone development, osteoblast regulation, and macrophage function.
It is integral to pathways regulating bone resorption and osteoclast activity.

Purpose of the Study:

To review the structure, distribution, regulation, and functions of ACP5.
To explore the role of ACP5 in human genetic diseases and cancer.
To identify ACP5 as a potential therapeutic target.

Main Methods:

Systematic literature review.
Searches conducted in PubMed and Medline databases.
Assessment of existing studies on ACP5.

Main Results:

RANKL upregulates ACP5 expression via NFATc1 and c-Fos, promoting osteoclastogenesis.
ACP5, with its phosphatase activity, mediates the development of genetic diseases and cancer.
Multiple regulators influence ACP5 activity.

Conclusions:

ACP5 is a significant target for preventing, monitoring, and treating tumors.
ACP5 holds promise for therapeutic strategies in human genetic diseases.
Further research is needed to clarify the precise mechanisms of ACP5 in cancer.