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Updated: Feb 12, 2026

Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
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Zika Virus Outbreak, Barbados, 2015-2016.

Sadie J Ryan1,2,3, Catherine A Lippi1,3, Colin J Carlson4,5

  • 1Emerging Pathogens Institute, University of Florida, Gainesville, Florida.

The American Journal of Tropical Medicine and Hygiene
|April 12, 2018
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Summary

Barbados experienced a significant Zika virus outbreak in 2016. The study analyzed 926 suspected cases, confirming 147 Zika infections, with women and children disproportionately affected.

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Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Diseases

Background:

  • Zika virus (ZIKV) rapidly spread throughout the Americas in 2015, impacting Caribbean nations.
  • Barbados reported its first autochthonous Zika transmission in January 2016, preceding the global health emergency declaration.

Purpose of the Study:

  • To describe the epidemiological characteristics of suspected Zika virus cases in Barbados.
  • To analyze laboratory-confirmed Zika infections and identify demographic patterns.

Main Methods:

  • Retrospective analysis of 926 clinical case records initially suspected as Zika.
  • Laboratory confirmation using reverse transcription-polymerase chain reaction (RT-PCR).

Main Results:

  • Out of 926 suspected cases, 147 were laboratory-confirmed positive for Zika virus.
  • Women constituted a higher proportion of suspected (71.9%) and confirmed (78.2%) cases.
  • Nineteen confirmed Zika cases were identified in children under 10 years old.

Conclusions:

  • The epidemiological data provides insights into the Zika virus burden in Barbados during the 2016 outbreak.
  • The findings highlight a notable prevalence in women and young children, suggesting potential areas for targeted public health interventions.