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Skin reactions to co-trimoxazole
1Universitäts-Hautklinik der Albert-Ludwigs-Universität, Freiburg i. Br.
Infection
|January 1, 1987
Summary
Co-trimoxazole can cause severe skin reactions like Stevens-Johnson syndrome and Lyell
Area of Science:
- Dermatology
- Epidemiology
- Pharmacovigilance
Background:
- Co-trimoxazole is associated with various allergic skin reactions.
- Severe reactions, Stevens-Johnson syndrome (SJS) and Lyell's syndrome (LS), carry significant mortality risks (1% and 30% respectively).
Purpose of the Study:
- To estimate the incidence of drug-induced severe skin reactions, specifically SJS and LS, in Germany.
- To assess the role of co-trimoxazole in causing these severe reactions.
Main Methods:
- An extensive epidemiological survey was conducted in Germany between 1981 and 1985.
- Data were collected from dermatology, burns, and intensive care units, achieving a 92% registration rate.
Main Results:
- The annual incidence was calculated as 0.8 per million for LS and 1.0 per million for SJS.
- Co-trimoxazole was identified as a significant factor, ranking high for LS induction and mid-range for SJS induction.
Conclusions:
- Co-trimoxazole poses a notable risk for severe, potentially fatal skin reactions.
- The study provides crucial data on the incidence and risk factors for SJS and LS.