Related Experiment Video
Updated: Feb 12, 2026

Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
RELATIVE BIOAVAILABILITY OF RISEDRONATE SODIUM ADMINISTERED IN SUPERABSORBENT COPOLYMER PARTICLES VERSUS ORAL
Abstract:
In this study, sustained release superabsorbent copolymer particles have been prepared and analyzed to increase bioavailability of orally administered risedronate sodium. Formulations were prepared by free radical polymerization of combination of 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA), polyvinyl pyrrolidone (PVP) / chitosan (CTS) by using ethylene glycol dimethacrylate (EGDMA) as crosslinker, potassium persulfate as initiator, and N,N,N,N-tetramethylethylene diamine as activator. Formulations were successfully loaded with risedronate sodium. Formulations as gel particles encapsulated in hard gelatin were analyzed to estimate drug content. The maximum plasma drug concentration (C.) and its corresponding time (Tmax.), area under the curve and relative bioavailability (with reference to oral solution of drug administered) were calculated. It was found a marked increase in Tmax. with lower Cmax. that confirmed the multiparticulte system to deliver drug at controlled rate. The results of relative bioavailability after oral administration of these formulations indicated a remarkable increase in the bioavailability.
More Related Videos
10:53Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
06:39Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
Related Concept Videos
Bioavailability Study Design: Absolute Versus Relative Bioavailability
Bioavailability Study Design: Healthy Subjects Versus Patients
Enthalpy of Solution
Intermolecular Forces in Solutions
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
Calculating pH Changes in a Buffer Solution
Subatomic Particles