Related Experiment Video
Updated: Feb 12, 2026
08:11
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
Published on: November 14, 2016
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Emerging drugs for primary progressive multiple sclerosis.
Ram Narendra Narayan1, Thomas Forsthuber2, Olaf Stüve1,3,4
1a Department of Neurology and Neurotherapeutics , University of Texas Southwestern Medical Center , Dallas , TX , USA.
Expert Opinion on Emerging Drugs
|April 12, 2018
Summary
Identifying effective therapies for progressive multiple sclerosis (MS) requires understanding pathogenesis, improving animal models, and innovative trial designs. Ocrelizumab
Area of Science:
- Neurology
- Immunology
- Neuroscience
Background:
- Progressive multiple sclerosis (MS) presents significant therapeutic challenges.
- Understanding the pathogenesis of primary progressive MS (PPMS) is crucial for developing effective treatments.
- Current therapeutic strategies for PPMS are limited.
Purpose of the Study:
- To review current knowledge on pathogenic mechanisms in PPMS.
- To summarize the rationale and outcomes of key clinical trials in PPMS.
- To outline future perspectives for PPMS therapy.
Main Methods:
- Literature review of pathogenic mechanisms in PPMS.
- Analysis of Phase II and III clinical trial data for PPMS.
- Synthesis of expert opinion on current and future therapeutic strategies.
Main Results:
- Ocrelizumab represents a significant advancement in PPMS therapy, highlighting the importance of patient selection.
- Effective PPMS therapy may require a combination of immune-modulatory, myelin-restorative, and neuro-regenerative approaches.
- Early intervention is likely key for successful therapeutic outcomes.
Conclusions:
- A comprehensive understanding of PPMS pathogenesis and innovative therapeutic strategies are needed.
- Combination therapies, including immune modulation and neuro-regeneration, show promise.
- Careful patient selection, outcome monitoring, and early treatment are critical for managing PPMS.
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