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Updated: Feb 12, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Effect of Hydroalcoholic Extracts of Capsella Bursa-Pastoris on Heavy Menstrual Bleeding: A Randomized Clinical Trial
Mahdis Naafe1, Nourossadat Kariman2, Zohreh Keshavarz2
11 Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
Insights
Capsella bursa-pastoris significantly reduced heavy menstrual bleeding (HMB) compared to placebo. This natural extract offers a promising approach for managing HMB and improving women's quality of life.
Area of Science:
- Herbal Medicine
- Gynecology
- Pharmacology
Background:
- Heavy menstrual bleeding (HMB) significantly impacts women's quality of life and can lead to iron deficiency anemia.
- Identifying effective and safe treatments for HMB is crucial for women's health.
Purpose of the Study:
- To evaluate the efficacy of hydroalcoholic extracts of Capsella bursa-pastoris in managing heavy menstrual bleeding (HMB).
Main Methods:
- A triple-blinded, randomized clinical trial was conducted with 84 participants diagnosed with HMB.
- Participants received either Capsella bursa-pastoris capsules with mefenamic acid or mefenamic acid with a placebo for two consecutive cycles.
- Menstrual blood loss was assessed using the pictorial blood loss assessment chart (PBLAC), alongside tracking bleeding days and participant satisfaction.
Main Results:
- Both groups showed a significant decrease in menstrual bleeding after the intervention.
- The reduction in menstrual bleeding was significantly greater in the group treated with Capsella bursa-pastoris (p < 0.001).
Conclusions:
- Hydroalcoholic extracts of Capsella bursa-pastoris demonstrated significant effectiveness in reducing menstrual bleeding.
- Further research is warranted to confirm the efficacy and safety of Capsella bursa-pastoris for HMB management.
Objectives:
Heavy menstrual bleeding (HMB) is one of the leading causes of low quality of life and iron deficiency anemia in women. This study aimed to determine the effect of hydroalcoholic extracts of Capsella bursa-pastoris on HMB.
Design:
This study is a triple-blinded, randomized clinical trial.
Setting:
The study was conducted in gynecology clinics affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Subjects:
Our patients affected to a complaint of HMB. After obtaining a complete medical history of the women and filling out the demographic forms, the participants were assigned randomly into the experimental (n = 42) and control groups (n = 42).
Intervention:
The eligible participants were given a pictorial blood loss assessment chart (PBLAC) to confirm HMB during the menstrual cycle. The experimental group received two capsules of mefenamic acid (500 mg) every 8 h and two Capsella bursa-pastoris capsules every 12 h. The intervention started from the first day of menstruation to the end of this period up to 7 days for two consecutive cycles. In the control group, the patients received mefenamic acid and placebo instead of Capsella bursa-pastoris capsules.
Outcome Measurements:
The PBLAC score and number of bleeding days, incidence of any possible problems, as well as participant satisfaction were measured. The data were analyzed using t-test, Chi-square, repeated-measures ANOVA, and ANCOVA tests in PASW Statistics ver. 18.
Results:
After the intervention, there was observed significant decrease in the amount of menstrual bleeding in both groups. However, the mean decrease in the amount of bleeding was significantly more in the Capsella bursa-pastoris group (p < 0/001).
Conclusion:
Compared with control group, hydroalcoholic extracts of Capsella bursa-pastoris capsule appeared to be effective in reducing menstrual bleeding in this study. Further research regarding the efficacy and safety of Capsella bursa-pastoris is required.
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