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Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Pigmented squamous cell carcinoma: case report and importance of differential diagnosis
Patrícia Motta de Morais1, Antônio Pedro Mendes Schettini1, Jeanine Alvarenga Rocha2
1Division of Histopathology at Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.
Abstract:
A few cases of pigmented squamous cell carcinoma affecting the skin and the ocular and oral mucosa of the elderly have been described in the literature. The disease manifests itself as papular and nodular erythematous or pigmented lesions. The main clinical differential diagnoses are pigmented basal cell carcinoma and melanoma. Histopathological examination is characterized by proliferation of atypical squamous cells with formation of horn pearls permeated by dendritic melanocytes. For this reason, a careful diagnosis is necessary to rule out other tumors that show melanin pigment. Surgical removal is the indicated treatment and the prognosis is similar to the classical squamous cell carcinoma. We report a case of pigmented squamous cell carcinoma with diagnosis confirmed by histological and immunohistochemical examinations.
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